Peak oxygen consumption (pVO2)
is one predictor of mortality in obstructive hypertrophic cardiomyopathy (HCM)1,2
Increases in pVO2 can help improve the lives of people with HCM.3,4
Eric,
Diagnosed with HCM in 2023
Actual consented patient.
The American Heart Association/American College of Cardiology (AHA/ACC)/Multisociety 2024 Guidelines identify improved exercise tolerance as one consideration of HCM treatment5*
Clinical trials for HCM therapies increasingly use pVO2 as a key measure5
pVO2 is one predictor of mortality in obstructive HCM and is an objective and reproducible measure of functional capacity1,2
In a single-center observational cohort study† of more than 1800 people with HCM, the risk of mortality or cardiac transplantation was reduced by 21% for each 1.0 mL/kg/min increase in pVO21
Studies support a 1 mL/kg/min improvement in pVO2 as having a clinically meaningful effect1,6
Silent No More: Provoking Symptoms in Obstructive HCM
Watch 2 HCM specialists discuss the relative clinical value of different approaches for diagnosing HCM.
People with HCM often have low exercise tolerance, resulting in a reduced ability to perform daily activities of living, such as grocery shopping, mowing the lawn, or carrying something upstairs.6-10
Next: Explore how whole-person care can make a difference
Clinical decisions remain with the healthcare provider.
*Multisociety includes American Medical Society for Sports Medicine, Heart Rhythm Society, Pediatric and Congenital Electrophysiology Society, and Society for Cardiological Magnetic Resonance.5
†This was a single center, observational cohort study in 1898 patients with HCM who underwent cardiopulmonary exercise testing (CPET) from 1998 through 2010 and were followed to mid-2013 (median follow-up 5.6 years) for the endpoint of all-cause mortality or cardiac transplantation.1
References: 1. Coats CJ, Rantell K, Bartnik A, et al. Cardiopulmonary exercise testing and prognosis in hypertrophic cardiomyopathy. Circ Heart Fail. 2015;8(6):1022-1031. doi:10.1161/CIRCHEARTFAILURE.114.002248 2. Tompkins JDV, Day SM, Jacoby DL, et al. Peak oxygen consumption is an independent predictor of survival and outcomes in obstructive and non-obstructive hypertrophic cardiomyopathy (HCM) patients: results from the international sarcomeric human cardiomyopathies registry (SHaRe). Circulation. 2018;138(suppl 1): Abstract 14251. 3. Spertus JA, Jones PG, Sandhu AT, Arnold SV. Interpreting the Kansas City Cardiomyopathy Questionnaire in clinical trials and clinical care: JACC state-of-the-art review. J Am Coll Cardiol. 2020;76(20):2379-2390. doi:10.1016/j.jacc.2020.09.542 4. Huff CM, Turer AT, Wang A. Correlations between physician-perceived functional status, patient-perceived health status, and cardiopulmonary exercise results in hypertrophic cardiomyopathy. Qual Life Res. 2013;22(3):647-652. doi:10.1007/s11136-012-0182-y 5. Ommen SR, Ho CY, Asif IM, et al. 2024 AHA/ACC/AMSSM/HRS/PACES/SCMR guideline for the management of hypertrophic cardiomyopathy: a report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Circulation. 2024;149(23):e1239-e1311. doi:10.1161/cir.0000000000001250 6. Coats CJ, Maron MS, Abraham TP, et al. Exercise capacity in patients with obstructive hypertrophic cardiomyopathy: SEQUOIA-HCM baseline characteristics and study design. JACC Heart Fail. 2024;12(1):199-215. doi:10.1016/j.jchf.2023.10.004 7. Jette M, Sidney K, Blümchen G. Metabolic equivalents (METS) in exercise testing, exercise prescription, and evaluation of functional capacity. Clin Cardiol. 1990;13(8):555-565. doi:10.1002/clc.4960130809 8. Morey MC, Pieper CF, Cornoni-Huntley J. Is there a threshold between peak oxygen uptake and self-reported physical functioning in older adults? Med Sport Exer. 1998:30(8):1223-1229. 9. Herrmann SD, Willis EA, Ainsworth BE, et al. 2024 Adult Compendium of Physical Activities: a third update of the energy costs of human activities. J Sport Health Sci. 2024;13(1):6-12. doi:10.1016/j.jshs.2023.10.010 10. Herrmann SD, Willis EA, Ainsworth BE, et al. 2024 Adult Compendium of Physical Activities: a third update of the energy costs of human activities. J Sport Health Sci. 2024;13(1)(suppl):6-12.